Pemeriksaan Imunologi Terhadap Kadar Hormon Thyroid Stimulating Hormone (TSH) Pada Pasien Gangguan Tiroid Di RSUD Panembahan Senopati Periode 2020-2022
Abstract
Thyroid disorders are conditions of abnormalities in thyroid gland. According to function, thyroid disorders are divided into three, hyperthyroidism, hypothyroidism and euthyroidism. To detect thyroid disorders, can use laboratory test examination of TSH (Thyroid Stimulating Hormone) hormone. The aim is to determine the description of TSH levels checked periodically in patients with thyroid disorders using immunological methods. Research method is a case series method or case-by-case using secondary data from TSH hormone examination results in 2020-2022. The results were from 93 respondents based on age showed that 20-30 years old 11.8%, 31-40 years old 26.9%, 41-50 years old 26.9% and 51-60 years old 34.4%. Based on gender, 20.4% were male and 79.6% were female. Then we looked at changes in TSH hormone in patients with thyroid disorders by randomization 10 respondents. It was found that the changes were caused by consumption of anti-thyroid drugs, Thiamazole, Propranolol, Thyrozol, Propylthiouracil, Levothyroxine. Respondents with thyroid disorders were mostly found in 51-60 years and were female. There are changes in TSH hormone levels in patients with thyroid disorders were anti-thyroid drugs. The immunological method used ECLIA (Electrochemiluminescence Immunoassay) method. Factors that influence examination are the condition of sample and patient.
References
Abubakar, H., Singh, V., Arora, A., & Alsunaid, S. (2017). Propranolol-Induced Circulatory Collapse in a Patient with Thyroid Crisis and Underlying Thyrocardiac Disease: A Word of Caution. Journal Of Investigative Medicine High Impact Case Reports, 5(4), 2324709617747903. https://doi.org/10.1177/2324709617747903
Arianti KY, Prihandani S, Hakim NR. (2021). Hubungan Keluarga dengan Tingkat Kecemasan Pasien Pre Operasi Thyroidektomy di Klinik Bedah RSD Mangunsada Kabupaten Bandung. J NursUpdate. 12(1):22-34.
Assagaf, S. M., Lumintang, N., & Lampus, H. (2015). Gambaran Eutiroid Pada Pasien Struma Multinodusa Non-Toksik Di Bagian Bedah Rsup Prof. Dr. R. D. Kandou Manado Periode Juli 2012 Juli 2014. E-CliniC, 3(3). https://doi.org/10.35790/ecl.v3i3.9422
BPOM RI Pusat Informasi Obat Nasional. (2015). Antitiroid. Tersedia dalam https://pionas.pom.go.id/ioni/bab-6-sistem-endokrin/62-hormon-tiroid-dan-antitiroid/622-antitiroid . Diakses pada 10 Agustus 2023.
Dirjen Kemenkes. (2015). Bebaskan Dirimu dari Gangguan Tiroid https://kesmas.kemkes.go.id/konten/133/0/052714-bebaskan-dirimu-dari-gangguan-tiroid. www.kemenkes.go.id. Diakses pada 10 Agustus 2023.
Farida, S dan Sakti, T, P., (2016). Oftalmopati pada Penyakit Graves. Jurnal Kedokteran 2016, Vol 5 No. 3: 27-30 ISSN 2527-7154.
Fidianti, F. (2022). Korelasi Kadar Thyroid Stimulating Hormone (TSH) dan Kadar Free Thyroxine (FT4) Pada Pasien Tiroid di RS Bhayangkara TK. I Raden Said Sukanto. Skripsi. Fakultas Ilmu Kesehatan dan Teknologi. Universitas Binawan. Jakarta
Hidayat, T., Susbiantonny, A., Yunitawati, D., (2015). Pengaruh Ekstrak Etanol Ciplukan Terhadap Penurunan Kadar Thyroid Stimulating Hormone (TSH) Tikus Jantan Galur Wistar Induksi Propylthiouracil. Jurnal MGMI Vol. 7, No. 1, Desember 2015: 11-24.
Irsan, E. M. (2014). Hubungan Penggunaan Propranolol Pada Penderita Hipertiroid Terhadap Tingkat Depresi di Poli Endokrinologi Metabolik Dan Diabetesrnblud Dr. Zainoel Abidin Banda Aceh. Fakultas Kedokteran. Universitas Syiah Kuala. Aceh
Juwita, A, D., Suhatri, Hestia, R. (2018). Evaluasi Penggunaan Obat Antitiroid pada Pasien Hipertiroid di RSUP Dr. M Djamil Padang Indonesia. Jurnal Sains Farmasi dan Klinis Vol 5 No. 1 April 2018 49-54.
Kam, Alexander. (2018). Pengaruh Pemberian Terapi Inisial Propylthiouracil terhadap Kadar Thyroid-Stimulating Hormone (TSH) dan Kadar Thyrotropin-Releasing Hormone (TRH) pada Penyakit Graves. Thesis. Universitas Andalas.
Krasowski M. D. (2019). Educational Case: Hemolysis and Lipemia Interference With Laboratory Testing. Academic pathology, 6, 2374289519888754. https://doi.org/10.1177/2374289519888754
Kurniawan, L.B, Arif M. (2015). Telaah Pustaka: Diagnosis Tiroid. Indonesian Journal of Clinical Pathology and Medical Laboratory Vol. 21 No. 3
Lembaga Kebijakan Pengadaan Barang/Jasa Pemerintah (LKPP). (2022). Generik Thiamazole/ Tiamazol Tablet Salut Selaput 5 mg. Tersedia dalam https://e-katalog.lkpp.go.id/katalog/produk/detail/48940017?lang=id&type=province . Diakses pada 10 Agustus 2023.
Leo, Simone De, Sun Y Lee, Lewis E Braverman, Endocrine Unit, and Clinical Sciences. (2016). Hyperthyroidism. HHS Public Access 388(10047): 906– 918.
Mahfirohayati. (2022). Penambahan Alfa-Siklodekstrin Pada Preparasi Serum Lipemik Untuk Pemeriksaan Kadar Glukosa. Skripsi. Poltekkes Kemenkes Yogyakarta.
Mary, S. (2023). Why Your Thyroid Hormone Levels May Be Fluctuating: 8 Reasons You May Not Be Aware Of. Verywellhealth.com. Tersedia dalam https://www.verywellhealth.com/when-your-thyroid-levels-are-fluctuating-3232909 . Diakses pada 10 Agustus 2023.
Munawirah, A., Muhiddin, H.S., Kurniawan, L.B., Pakasi, R.D.N. 2019. Interferensi Sampel Lipemik pada Bayi dengan Lipemia Retinalis Dikarenakan Primary Mixed Hyperlipidemia: Laporan Kasus. Intisari Sains Medis 10(2): 413-419. DOI: 10.15562/ism.v10i2.370
Naully dan Khairinisa. (2018). Panduan Analisis Laboratorium Imunoserologi untuk D3 Teknologi Laboratorium Medis. Karya Tulis Ilmiah. Stikes Jenderal Achmad Yani Cimahi. Cimahi
Novell Pharmaceutical Laboratories. (2023). Informasi Produk Thiamazole 5 mg dan 10 mg. Tersedia dalam https://e-katalog.lkpp.go.id/katalog/produk/detail/48940017?lang=id&type=province . Diakses pada 10 Agustus 2023
Prajayanti, DM. (2020). Gambaran Kadar Thyroid Stimulating Hormone pada Pasien Disfungsi Tiroid di Laboratorium Klinik Niki Diagnostic Center Denpasar. Karya Tulis Ilmiah. Politeknik Kesehatan Denpasar.
Prumnastianti G dkk. (2021). Hubungan Gangguan Fungsi Tiroid Terhadap Kadar LDL Kolesterol. Jurnal SainHealth, vol. 5, no. 2, Sep. 2021, pp. 6-12, doi:10.51804/jsh.v5i2.1018.6-12.
Pusat Data dan Informasi Kementrian Kesehatan RI (PUSDATIN). (2015). Situasi dan Analisis Penyakit Tiroid. Tersedia dalam www.kemkes.go.id/download.php?file=download/pusdatin/infodatin/infodatin-tiroid.pdf. Diakses pada 10 Agustus 2023.
Rajput, R., & Goel, V. (2013). Indefinite antithyroid drug therapy in toxic Graves' disease: What are the cons. Indian Journal Of Endocrinology And Metabolism, 17(Suppl 1), S88–S92. https://doi.org/10.4103/2230-8210.119513
Rama, Edwinantha. (2018). Perbandingan Efektivitas Obat Antitiroid Antara Tiamazol Dengan Propiltiourasil Terhadap Pasien Hipertiroid Yang Disebabkan Graves’ Disease di RSUD Cengkareng Periode 2017. Skripsi. Universitas Pembangunan Nasional Veteran Jakarta.
Wardana, A, C., dkk. (2023). Karakteristik Pasien Gangguan Fungsi Tiroid di RSUP Sanglah Tahun 2019. Jurnal Medika Udayana, Vol. 12 No.4, April, 2023. 65-70.
Wirawati, I. A. P. (2017). Pemeriksaan Tiroid. Karya Tulis Ilmiah. Fakultas Kedokteran. Universitas Udayana
Yonathan, Tubagus VN, Ali RH. (2017). Gambaran USG pada Pasien Nodul Tiroid di Bagian/SMF Radiologi FK UNSRAT RSUP Dr. R. D. Kandou Manado Periode Juni 2016 – Mei 2017. Jurnal e-CliniC 5 (2): 137-140
